Can a severe B12 deficiency cause numbness and tingling in the feet?
1. Introduction A pronounced deficiency in vitamin B12 leads directly to the demyelination of peripheral nerves, resulting in symmetrical numbness and tingling in the lower extremities. Vitamin B12, or cobalamin, is an essential water-soluble micronutrient fundamentally required for the maintenance of the nervous system and the synthesis of myelin. When serum cobalamin levels drop significantly, … Read more