Increased Prothrombin Time: Pathophysiology and Clinical Management

Increased Prothrombin Time: Pathophysiology and Clinical Management

1. Introduction An increased prothrombin time signifies a measurable delay in the ability of blood plasma to form a stable fibrin clot via the extrinsic coagulation pathway. In standard clinical practice, this finding indicates that the sequential activation of specific coagulation proteins, primarily synthesized by the liver, is operating with reduced efficiency. An elevated prothrombin … Read more