Infantile Malignant Osteopetrosis: Mechanisms, Diagnosis, and Treatment
1. Introduction Infantile malignant osteopetrosis is a severe, rare genetic disorder characterized by the failure of osteoclasts to resorb bone, leading to excessively dense but structurally fragile bones and profound systemic complications. The bottom line up front is that this life-threatening condition obliterates the bone marrow cavity and compresses vital cranial nerves, requiring rapid genetic … Read more