Combined Small Cell-Large Cell Carcinoma: Diagnosis, Staging, and Management
1. Introduction Combined small cell-large cell carcinoma is a rare, biphasic malignancy of the pulmonary system characterized by the aggressive proliferation of two distinct cellular lineages within the same tumor mass. The tumor comprises classical small cell carcinoma elements existing simultaneously with large cell carcinoma components. This dual histological presentation creates a uniquely aggressive clinical … Read more