Homozygous Beta Thalassemia Major: Pathophysiology, Symptoms, and Treatment
1. Introduction to Homozygous Beta Thalassemia Homozygous beta thalassemia, clinically recognized as thalassemia major or Cooley anemia, is a profound genetic blood disorder characterized by the complete absence or severe reduction of beta-globin chain synthesis. This biochemical failure drastically disrupts the formation of healthy red blood cells, leading to a state of severe, life-threatening microcytic … Read more