Diethylstilbestrol (DES) Exposure in Utero: Fetal Disorders and Risks

Diethylstilbestrol (DES) Exposure in Utero: Fetal Disorders and Risks

1. Introduction A fetal disorder caused by diethylstilbestrol transmitted via the placenta represents a profound chapter in the history of obstetrical pharmacology, highlighting the severe, delayed consequences of transplacental endocrine disruption. Diethylstilbestrol, a powerful synthetic, non-steroidal estrogen, was widely prescribed to millions of pregnant women between the late 1930s and the early 1970s under the … Read more