Holorachischisis: Pathophysiology, Diagnosis, and Clinical Management
1. Introduction to Holorachischisis Holorachischisis is a profound neural tube defect characterized by the complete failure of the spinal column to close during embryonic development. This congenital anomaly exposes the entire length of the spinal cord to the amniotic fluid, leading to severe, irreversible neurological impairment. It represents one of the most severe manifestations of … Read more