Kernicterus Due to Isoimmunization: Pathophysiology, Symptoms, and Prevention

Kernicterus Due to Isoimmunization: Pathophysiology, Symptoms, and Prevention

1. Introduction Kernicterus is a severe, preventable neurological condition characterized by the permanent deposition of unconjugated bilirubin within the basal ganglia and brainstem nuclei of a neonate. While mild jaundice is a common and typically benign transitional physiological state in newborns, an aggressive accumulation of bilirubin can cross the immature blood-brain barrier, resulting in profound … Read more