Why Do My Knuckles Feel Stiff and Difficult to Close After Waking Up?
1. Introduction Morning stiffness and difficulty closing the knuckles upon waking are primarily the result of nocturnal synovial fluid stasis and circadian inflammatory rhythms. During sleep, the lack of joint movement causes the lubricating fluid within the hands to cool and thicken, losing its normal viscosity. Simultaneously, natural morning peaks in inflammatory cytokines temporarily swell … Read more