Injection Site Fibrosis: Connective Tissue Remodeling and Treatment

Injection Site Fibrosis: Connective Tissue Remodeling and Treatment

1. Introduction Injection site fibrosis is a chronic, structural localized disorder characterized by the excessive deposition of dense connective tissue in the subcutaneous and dermal layers following repeated medical injections. Clinically presenting as firm, palpable, and poorly yielding localized nodules or plaques, this condition represents a maladaptive outcome of the body’s natural wound healing processes. … Read more