Rhabdoid Tumor (NOS): Genetics, Diagnosis, and Clinical Management
1. Introduction A malignant rhabdoid tumor is an exceptionally rare, highly aggressive pediatric neoplasm characterized by profound epigenetic dysregulation and a notoriously rapid clinical progression. The bottom line is that rhabdoid tumors are driven almost exclusively by the mutational loss of a single tumor suppressor gene, SMARCB1 (INI1), demanding an immediate, high-intensity, multi-modality treatment approach … Read more