Can hormonal changes cause severe hyperpigmentation on the upper lip?
1. Introduction Hormonal changes can directly cause profound hyperpigmentation on the upper lip, a distinct clinical condition diagnosed as melasma. This localized darkening occurs when fluctuating levels of estrogen and progesterone stimulate the melanocytes within the skin to overproduce melanin, the pigment responsible for skin color. The upper lip is uniquely sensitive to these hormonal … Read more