What Does Persistent Heartburn That Does Not Respond to Antacids Mean?
1. Introduction Persistent heartburn that does not respond to standard antacids indicates that the underlying pathology is likely refractory gastroesophageal reflux disease, severe mucosal inflammation, or a completely non-gastric issue such as cardiovascular ischemia. When chemical neutralizing agents fail to provide relief, it signifies that the lower esophageal sphincter is chronically failing, or that hypersensitive … Read more