Pyrexia of Unknown Origin (PUO): Diagnostic Challenges and Clinical Management

Pyrexia of Unknown Origin (PUO): Diagnostic Challenges and Clinical Management

1. Introduction Pyrexia of unknown origin, frequently abbreviated as PUO and also known as fever of unknown origin, remains one of the most intellectually demanding diagnostic challenges in modern medicine. This clinical condition is defined not just by the presence of a fever, but by a fever that stubbornly persists despite extensive, intelligent medical investigation. … Read more

When should I worry about an unexplained low-grade fever that lingers for days?

When should I worry about an unexplained low-grade fever that lingers for days?

1. Introduction A lingering, unexplained low-grade fever is a frequent clinical finding that often points to a mild, resolving viral infection, but it can occasionally signal the presence of a more insidious underlying inflammatory process or occult bacterial infection. You should worry and arrange for a thorough medical evaluation if the fever persists continuously for … Read more