What causes sudden swelling in the left leg and ankle?
1. Introduction and Direct Answer Sudden swelling localized specifically to the left leg and ankle is a significant clinical presentation most commonly caused by deep vein thrombosis, a potentially dangerous blood clot obstructing venous return. In the left leg, this vascular occlusion is uniquely exacerbated by May-Thurner syndrome, an anatomical variant where the right iliac … Read more